The Art Region is the selected are of the Artwork in Visualization.
This can be done by menu or using the Add New Art Region button.
Add Art Region from Opening: Art Regions Tab
Add Full Size Art Region: Art Regions Tab
Add New Art Region: Art Regions Tab
Clear Regions: Images Tab
Margin Size: Art Regions Tab
Selected Region: Art Regions Tab
Unassigned Openings: Art Regions Tab